Sample concentration normalisation and sample pooling (NGS)
PCR cleanup (AMPure, CleanNGS)
DNA Library Prep (Illumina)
Dilution series
Cherry-picking from various plates and formats
Multiple mastermixes preparation
Intuitive setup wizard with drag and drop programming
Prepare PCR reactions for all common qPCR cyclers
Use any type of sample/PCR plate (96, 384, deep-well etc)
Use any type of reagent tube from 0.1 ml to 15 ml
Import experiment setup into a ready to use template (csv file)
Export experiment to any qPCR cycler, also via LIMS (csv file)
Size
A dynamic design with style and function. At less than 17 kg and a footprint of less than 2,500 cm2, Myra9 is half the size of other in class liquid handling systems. A closed pipette tip waste container minimises the footprint area and reduces contamination risk. UV LED lights and a compact HEPA filter reduce the chances of qPCR contamination. The compact design of both parts reduces size and weight of the Myra unit.
The core capabilities of MyraIntelligence®
Pipetting is more than a mechanical task — it’s a precise balance of vision, touch, and judgment. It’s a nuanced process that blends motor control with cognitive insight, as operators instinctively adapt to fluid properties and positioning through sensory feedback and experience.
The AI-powered liquid handling system captures this complexity. With real-time computer vision and dynamic sensing, it identifies labware, reads liquid characteristics, and adjusts technique accordingly.
It doesn’t just execute commands — it perceives, adapts, and learns. The result is a smarter, more refined approach to liquid handling that preserves human finesse and scales it through intelligent automation.
MyraSim™ — The Expert Assistant
Dynamically calculate optimal volumes required to complete the run without fail
Analyzes every operation in your run to ensure every step will complete as expected – no surprises
Optimisation feedback suggestions for better run performance
Plan your run with confidence
MyraVision®— Eyes on Your Setup
Using advanced computer vision and AI learning models, MyraVision understands what’s on the deck
Intelligent checks for consumable type, missing plasticware and cap removal
Start your run with confidence
MyraSense™ — The Touch Behind Every Drop
Pressure based liquid level sensing for maximum security and precision
Optimised mix type selection based on liquid levels and tube type in real time
Intelligent tube height probing to avoid collisions and less time spent calibrating
Automated run recovery from unexpected collisions
Complete your run with confidence
Deck layout
Laying out your deck takes no time or effort. Select the plates you need or use a predefined default. Move your reagent components, intermediate mixes, and templates over to the plates and you’re done. Almost all plate positions can be used as a template, mix, reagent or reaction. This level of flexibility opens up a lot more room on your deck. We cater for most generic tube types so finding the right plate won’t be a problem.
You don’t find your tube type ? No problem – the software lets you define your own. How nice is that.
Case study: Illumina DNA Prep Kit
24 samples validation using the Illumina DNA Prep kit. Libraries displayed low variability across replicates, even barcode balance, and high coverage of sequence alignments.
Experimental setup
To demonstrate capability, 8-sample and 24-sample plates of 150 ng of input DNA (48 kB genome Lambda DNA and Human Genomic DNA) were prepared on the Myra Liquid Handling System. Manual preparation of an 8-sample plate of 150 ng of input DNA (48 kB genome Lambda DNA) was also performed as a comparison method. The quality of these libraries were checked with BiOptic Qsep1-Plus bio-fragment analyser (Figure 1). The libraries were quantified using NEBNext Library Quant Kit for Illumina with reaction setup on the Myra Liquid Handling System and amplification on the Mic qPCR Cycler. Libraries were simultaneously normalised and pooled to 2 M using the Myra Liquid Handling System, then sequenced on a 2×150 bp flow cell on an iSeq 100 System for whole genome sequencing. Q30 and percentage PF were used to show the quality of the libraries. Sequencing data was demultiplexed using Illumina’s BaseSpace Sequence Hub and coverage maps of the Lambda genome were analysed using Geneious Prime 2022.2.2.
Figure 1. Capillary electrophoresis gel of library quality analysed on BiOptic Qsep1-Plus with S2 Cartridge for 24-plax Lambda libraries. Consistent size and intensity was achieved for all 24 libraries indicating good library prep on the Myra liquid handling system.
Results
We were able to successfully generate high-quality 8-plex and 24-plex DNA libraries on the Myra, with comparative performance to the manual method (Figure 2). Fragment analyzer results show consistent fragment sizes across all 24 DNA libraries (Figure 1). The quality of the sequencing runs were comparative with Q30 score > 90% for all methods. Barcode balance was also accurate, with variability less than the manual method. Sequencing coverage of the Lambda genome also showed consistent uniformity across 8-plex and 24-plex DNA prep libraries constructed on the Myra. The sequence data showed low sample variability and reliable uniformity for libraries prepared using Illumina DNA Prep.
Figure 2. Mean library yield for DNA processed on Myra vs. manual preparation
The Myra liquid handling system comes with a comprehensive list of accessories, supporting most tubes and plates available on the market.
Calibration
Eye can do it. With a world first integrated high precision camera, achieving calibration on a liquid handling system has never been this easy. Simply click to the middle of the tube image, and let the software do the rest.
Only calibrate what you need. Why spend all day calibrating tubes you won’t even use. The Myra software will only require calibration of tubes that are in use. All calibration is recorded to the robot so no need to worry about doing it all again if you change computers or need to exchange the pipette head.
Performance
The key to excellent data starts with Accuracy and Precision. Accuracy is the ability to achieve the right value. Precision is the ability to reproduce the same value. For automated qPCR setup, you need to be able to do both – really well. The Myra pipetting robot can. The proof is in the results.
Precision
Means sample repeatability. With an automated pipetting precision of < 10% CV at 1 µl, the Myra robotic pipette will enhance your qPCR repeatability. Whether it’s for your gene expression studies or HRM genotyping, you will be confident in the data when setting up on the Myra pipetting robot.
Figure 3. KRAS human genomic DNA target. 10,000 copies per reaction. 48 replicates setup using 1 µl of template per 25 µl reaction. Cq = 19.23 | σ = 0.05 | Δmax-min= 0.25 | CV = 0.3%
Repeatability
Even at low copy number. Maintain confidence in your data even when you are working with samples that are influenced by the unavoidable Poisson distribution. The Myra automated qPCR setup ensures that the only significant bias in your experiments comes from the probability of aspirating the template and not the performance of the automated pipettor.
Figure 4. KRAS human genomic DNA target. 100 copies per reaction. Repeated three times. 48 replicates setup using 1 µl of template per 25 µl reaction. Cq = 25.35 | σ = 0.11 | Δmax-min= 0.60 | CV = 0.4%
Precise every time
Reproducible results to ensure experimental integrity. We know that the most important part of any scientific work is being able to reproduce your data. With the Myra liquid handler and Mic real-time PCR instrument, that’s exactly what we aim for. Achieve equivalent experimental setup each time, every time. Even when working with very low copy numbers.
Figure 5. KRAS human genomic DNA target. 100 copies per reaction. 48 replicates setup using 1 µl of template per 25 µl reaction. Cq = 25.39 | σ = 0.11 | Δmax-min= 0.65
Accuracy
Without compromising precision. Myra’s automated pipetting accuracy is specified to less than 10% for a 1 µl volume. But this does not come at the cost of reducing pipetting precision. Our world class pipetting head combined with low liquid retention tips, ensure best in-class liquid handling from a small and compact automated pipetting system.
Figure 6. Capricious gene. 7 point, 10 fold dilution series of the template run in replicates of 4. E = 97% ; R2 = 0.9999
Accuracy and precision maintained
Even at the extreme ! Push the limits of your automated qPCR. A 1.2 fold dilution series is now the norm, not the exception when using the Myra automated liquid handling system. With Myra’s amazing pipetting accuracy and precision combined with Mic’s incredible temperature uniformity ; uncommon has become routine.
Figure 7. Capricious gene. 8 point, 2 fold dilution series of the template run in replicates of 4. E = 96% ; R2 = 0.9993
The art of accuracy and precision
Be creative with your lab automation. With a robotic liquid handler capable of high pipetting accuracy and precision – we though we would be a little creative. So we decided to pipette a complex patterned dilution series to add a touch of flair to our already good looking robotic pipette. The result speaks for itself.
Figure 8. A complex pattern of various dilution factors from 10 fold to as low as 1.2 fold. E = 98% ; R2 = 0.9998
*coming soon
Automated qPCR setup
Standard applications like qPCR are built into the software to allow for quick setup. Setup your assays including run profiles and analysis. Myra can be configured to setup qPCR reactions in two different ways, depending on your unique laboratory settings:
1. Sample Prep and qPCR Setup is a feature that simplifies your complete workflow setup. The software automatically creates reactions based on user-defined sample input. The sample prep section means you can create a workflow from sample to reaction in only a few simple steps.
2. Reaction Driven qPCR Setup is a flexible option allowing users to create a customised reaction plate based on a desired sample order. Templates can be saved to facilitate routine work, then sample information can be simply imported from a .csv file.
NGS library prep
Achieve sample normalization, pooling, or simple plate transfers in a few steps. Alternatively, download and update existing protocols from BMS's list of script templates in order to bead purify your PCR reactions using the new BMS magnetic rack or automate more complex library preparation steps.
MyraScript is a new Python-based feature that can be used to develop fully customisable protocols. Full control of liquid transfer parameters, including pipetting speeds, delays, level sensing, tracking and mixing can be programmed by the user. Python is used in combination with a MyraScript API to configure plasticware and reagents on Deck Layout, and compile a list of operations for execution.
Visit Myra Script Library for access to an extensive collection of completed script runs for various protocols including matrix serial dilutions, complex normalisations, cell culture transfers, next-generation sequencing (NGS) applications and magnetic bead clean-up.
A small pipetting robot with a vision to perfection. The world’s first liquid handling system that can see.
Features :
Super compact with 8 SBS positions + waste tub
Best in class accuracy and precision, CV <5% at 1 ul and <1% above 5 ul
Flexibility without the complexity, easy programming with only few clics
Pressure based liquid level sensing that can monitor the aspirate and dispense process for errors
The first liquid handling system with an integrated camera and state of the art algorithms to enable Myra to see what it needs to do
Our website uses cookies to improve your user experience. By continuing to browse this website and clicking the CLOSE button, you declare to accept the use of cookies. LEARN MORE about how cookies are used on this website.
