Description
Concept
Precellys 24 Touch is the ideal lab instrument to homogenize any kind of biological sample, from the softest to the hardest, regardless of its origin (animal tissues, plant tissues, microorganisms…). It can treat up to 24 samples at a time and has been validated on more than 1,500 different samples: from brain, muscle and heart samples, to very hard material such as bones, hair and seeds.
The intuitive touchscreen interface of Precellys 24 Touch makes it really easy to use. Thanks to its exclusive vacuum-based tube locking system and its specific design, Precellys 24 Touch is compliant with safety requirements of the harshest lab environments, such as BSL3.
With its powerful 3D movement, Precellys 24 Touch provides high energy to the beads contained in the tubes, allowing the homogenization of the samples in a few seconds (~30 sec) at speeds ranging from 4,500 to 6,800 rpm. Samples can then be processed for further analysis amongst a wide variety of techniques dedicated to DNA/RNA (PCR, electrophoresis, NGS, chips, etc), protein (blotting, mass spectrometry, etc.), or metabolites analyses (chromatography, etc.).
Technology
The Precellys technology is based on two main features :
1- The 8-figure 3D-motion (multi-directional) movement of the tubes. The same high level of energy is given to the beads inside each tubes providing the same homogenization efficiency to all the processed samples (up to 24 at once). Thanks to this complex movement, the Precellys Evolution can disrupt any type of samples (even the hardest ones) in seconds with a perfect reproducibility in limiting heat generation.
2- The patented locking vacuum system of the tubes during the process. The Press’n block system helps the user saving time and energy. It eases the handling of the equipment and secures the tubes before the grinding process.
Advantages
- Full application support gathering 2,000+ scientific documents based on user experiences to determine the best protocol for your samples
- 30+ different lysing kits available, Precellys is the most versatil range of homogenizers
- The easy-handling features allow the Precellys to be used without any advanced training
- 20 years of expertise in sample preparation and 30,000+ scientists using the Precellys worldwide
Specifications
| Capacity | From 1 to 24 tubes of 2.0 ml or 0.5 ml |
|---|---|
| Speed range | From 4,000 to 6,800 rpm - increment of 100 rpm |
| Locking system | Automatic tubes locking system – patented |
| Programs | Unlimited (automatically saved after use) |
| Number of cycles | Up to 10 cycles |
| Cycles time | from 5 sec to 90 sec |
| Noise | <70 dB |
| Display | 5" color touchscreen |
| Power requirement | 90 – 230 VAC / 50-60 Hz, Power : 1 kVA |
| Dimensions (W x D x H) | 40.8 x 28.7 x 39.0 cm / 51.5 cm with opened lid |
| Weight | 23 kg |
Applications
Cancer research
Hard tissues such as those derived from tumors can be particularly difficult to homogenize, and many cancer researches utilize animal models. Precellys homogenizer is perfectly adapted to such applications.
Most soft tissue types such as liver, spleen or pancreas are relatively easy to homogenize. However, hard tissues such as those derived from tumors can be particularly difficult to homogenize, and many cancer researchers utilize animal models such as mouse, rat, etc., to study cancer progression. Complete homogenization is needed to extract high quality DNA, RNA or protein for further downstream processing. For applications such as microarray or sequencing analysis, it is important to maintain reproducibility amongst biological replicates during nucleic acid extraction.
Agronomy
Agronomy researches gathering GMO analysis, food allergies and plant studies, often require to grind hard samples such as seeds, roots or frozen food which are particularly hard to grind.
Most soft samples types such as leaves are relatively easy to homogenize. However, hard samples such as seeds, roots or frozen food can be particularly difficult to grind. Complete grinding in dry or liquid conditions is needed to extract high quality DNA, RNA or protein for further downstream processing. For applications such as microarray or sequencing analysis, it is important to maintain reproducibility amongst biological replicates during nucleic acid extraction. It is particularly interesting to identify species, GMO and understand their development mechanisms. Moreover, allergen studies can be performed more efficiently thanks to the capacity to grind in dry condition.
Forensic
Extremely hard samples such as bone, teeth, and hair are common in forensic laboratories. Popular downstream applications include DNA extraction from bone or teeth and drug extraction from hair.
Extremely hard samples such as bone, teeth, and hair are common in forensic laboratories, and downstream applications include DNA extraction from bone or teeth and drug extraction from hair. Biological evidence is available in small quantities, and it is a challenge to extract high quality DNA from scarce, organic material.
In patients suffering from alcohol abuse, monitoring abstinence while undergoing alcohol withdrawal treatments is followed closely by physicians. Precellys homogenizer is used to extract ethylglucuronide (EtG), a highly specific alcohol biomarker, from hair samples using liquid chromatography tandem mass spectrometry. Precellys can be used to dry grind hard samples such as bone or hair, which typically represents a challenge for many forensics laboratories, and offers an alternative solution to improving DNA and drug extraction yields from scarce biological material.
Pharmacology
Pharmaceutical research starts with molecule leads identifications either from natural model or artificial.
In both cases, the DMPK or animal toxicology models analysis, require to homogenize tissues.
In preclinical dermatological research for instance, complete skin homogenization is critical to determine the amount of compound delivered into the dermis and epidermis, which helps select for the best formulation prototype. The mass spectrometry analysis is often used for such application.
In addition to the capabilities of the Precellys to homogenize animal tissue, these instruments can also be used for micro or nano-milling of poorly water-soluble drugs to enhance bioavailability in pharmacokinetic studies. In clinical formulation development, the amount of active pharmaceutical ingredient (API) is often limited, and co-micromilling or nano-milling with various pharmaceutical excipients has been tested on the Precellys to increase solubility and dissolution rate of poorly water-soluble drug compounds.
Environment
Soil and environmental analysis often focus on microbiology studies and pollution impact on wildlife.
Microorganisms included in a biological matrix are particularly challenging to lyse.
Lysing microorganisms that are included in biological matrixes such as leaves can be particularly difficult to homogenize, and many environmental analysis utilize plant models to study microbial expansion and its potential impacts on wildlife. Complete lysing is needed to extract high quality DNA, RNA or protein for further downstream processing. For applications such as microarray or sequencing analysis, Precellys homogenizers help to maintain reproducibility amongst biological replicates during nucleic acid extraction.
Microbiology
Microorganisms studies are critical as they are used for bio-production or health researches. They are difficult to lyse due to their thick cell wall, which makes nucleic acid extraction difficult.
Microorganisms are difficult to lyse due to their extremely small size and their thick cell wall which makes nucleic acid extraction complicated. Precellys equipment and adapted lysing kits containing small (< 1 mm) glass beads to offer a real rapid and effective alternative to usual methods as chemical lysis or manual grinding. As Precellys solutions were initially designed for BSE diagnosis, it was mandatory to be able to work in BSL3 laboratories. This unique feature allow the Precellys to be used for infective and virulent microorganisms studies. Today, Precellys 24 or Precellys Evolution can be used in BSL4 laboratories, the ones working on HIV or Ebola.
